The Human Research Protection Program (HRPP) reviews and monitors research involving human subjects at UCSF and several affiliate institutions to ensure the welfare, safety, privacy, and ethical treatment of participants in human research studies. Read more about the HRPP program.
The HRPP is comprised of 3 groups:
- Institutional Review Board (IRB), which reviews human subject research studies — learn how to submit to the IRB.
- Quality Improvement Unit (QIU), which conducts monitoring, education and other QI activities.
- Human Gamete, Embryo and Stem Cell Research (GESCR) Committee.
Grant or Contract Termination Notices
What steps should I take with the IRB if I receive a grant or contract termination notice for a study involving participants?
| The research will be stopped, but study participants are still engaged in procedures, follow-up visits, or safety-related monitoring. |
Submit a Reporting Form. Report the change in study status and describe the measures you are taking to ensure a safe tapering or termination of study procedures for participants. Include the agency termination notice and a projected timeline for closing the study. Note:
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| All study activities have stopped, and there are no safety concerns. | Submit a Study Closeout Report. |
| The study team plans to continue treatment or other study activities despite the loss of funding. | Submit a Modification Form to update the funding source and any changes to the protocol. |
| Study procedures will continue per protocol while an appeal is in process. | Do not submit a modification to change the funding source unless 90 calendar days have passed without a formal decision on the appeal. |
Priority Review for Research on the Health Impact of Changes in Federal Policies since January 2025 and Dobbs Impact Research
The HRPP has appointed a Rapid Review Team (RRT) to ensure Research on the Health Impact of Changes in Federal Policies since January 2025 and Dobbs Initiative Related Research is fast tracked to approval. See instructions on how to request rapid review for studies falling under these categories.
